.jpg?width=618&height=184&name=SI_Final-2%20(1).jpg)
Dual Polyphenol Sports Recovery Ingredient
Gremin® is a clinically validated, plant-based ingredient that combines green coffee bean extract and curcumin into one synergistic actives system. A single 500 mg daily dose delivers faster muscle recovery, greater strength, and measurable endurance gains, all backed by two human clinical studies.
What is Gremin®?
Gremin® is a proprietary, patented ingredient that co-processes green coffee bean extract (standardized to chlorogenic acid) with curcumin from turmeric (standardized to curcuminoids) into a single food-ingredient carrier. It is the first commercially available dual polyphenol system built specifically for the sports and active nutrition category. Two human clinical studies and two preclinical studies validate its efficacy at a 500 mg daily dose.
Built on Bio-Fusion Technology
The two actives are infused together into a food-grade matrix so they work as one. This co-processing approach delivers both polyphenols in every serving without asking formulators to stack and balance two separate raw materials.
Clinically Validated in Humans
A 14-day, 60-subject randomized, double-blind, placebo-controlled study showed significant gains in 6-minute walk test distance, isometric muscle strength, and DEXA-measured lean body mass, along with reductions in fatigue and the muscle-damage marker lactate dehydrogenase.
Natural, Vegan, Clean Label
Gremin® is 100% plant-derived and fits vegan, vegetarian, and natural positioning. Its neutral profile and water dispersible powder format allow it to integrate into protein mixes, RTDs, gummies, and stick packs without compromising label claims.
Works Solo or With Protein
Gremin® is effective as a standalone recovery actives system and was designed to blend with protein supplements. That gives brands a single ingredient lever for muscle recovery, endurance, and lean mass claims in one SKU.
Two actives. One synergistic system.
Gremin® is not a blend in a bag. Its two polyphenols target different pathways in exercise recovery, then work together to cover the full recovery window from oxidative stress to inflammation to energy metabolism.
Chlorogenic acid is a polyphenol linked to reduced oxidative stress, improved glucose and lipid metabolism, and support for muscle mitochondrial function during resistance training.
- Antioxidant activity during intense training
- Efficient energy use during exercise
- Mitochondrial support in muscle tissue
- Anti-inflammatory activity post-exercise
Curcumin has been reviewed in a meta-analysis of 14 clinical studies for its ability to mitigate skeletal muscle damage, with improvements in creatine kinase, soreness, IL-6 levels, and range of motion.
- Mitigates exercise-induced muscle damage
- Reduces delayed onset muscle soreness
- Supports IL-6 and inflammatory balance
- Improves range of motion after training
The Fusion Outcome
When co-processed into Gremin®, these two polyphenols deliver benefits neither has shown alone in clinical work: significant 6-minute walk test gains, isometric strength increases, DEXA-measured lean body mass improvement, and reductions in fatigue and muscle-damage markers, all at a single 500 mg dose.
14 days. Measurable changes. Placebo controlled.
In the Fortune Journal of Health Sciences study, 60 healthy adults were randomized to 500 mg Gremin® or placebo once daily for 14 days. Gremin® outperformed placebo across endurance, strength, fatigue, and recovery markers.
Study Highlights
-
6-Minute Walk Test
Distance and speed significantly higher in the Gremin® group at Day 14 compared to both baseline and placebo.
-
Lean Body Mass (DEXA)
Lean body mass and fat-free mass significantly increased from baseline in the Gremin® group as measured by DEXA scan.
-
Muscle Damage Marker
8.4% reduction in LDH in the Gremin® group, compared to a non-significant 3.6% in placebo.
-
Mental Fatigue
Scores dropped 45.8% in the Gremin® group versus 11.1% in placebo, with significant differences at Day 14.
-
Safety
No clinically significant changes in vitals, CBC, liver enzymes, or serum creatinine. No treatment-related adverse events.
A single, branded actives system for the recovery shelf.
Sports nutrition shelves are crowded with single-active recovery products. Gremin® gives brands a clinically validated, naturally derived dual polyphenol story in one powder.
One Ingredient, Multi-Benefit Claims
Instead of stacking separate recovery, endurance, and anti-fatigue ingredients, brands can anchor a full claim set on a single, clinically studied actives system.
- Strength + endurance in one
- Recovery + fatigue reduction
- Simpler ingredient decks
Two Human Clinical Studies
Gremin® has been evaluated in a 60-subject healthy-adult study and a 16-subject eccentric-exercise study. Both used randomized, double-blind, placebo-controlled designs.
- Peer-reviewed publications
- CTRI registered trials
- Safety profile documented
Fast Results at a Low Dose
Measurable changes in strength, walk-test, fatigue, and inflammation markers at 500 mg once daily within 14 days. Low inclusion keeps formulation costs and label space tight.
- 500 mg clinical dose
- Easy to hit in sticks, caps, RTDs
- Visible 14-day window
Pairs Cleanly With Protein
Gremin® is designed to synergize with whey, plant, and beef protein formats. Formulators get a recovery and endurance story without compromising the protein system already in place.
- Protein powder compatible
- Neutral in RTDs
- Works in stick packs and bars
Natural, Vegan, Clean Label
100% plant-derived, vegan friendly, and produced in a GMP-certified, FDA-registered facility. An honest natural story for brands that refuse to rely on synthetic recovery stacks.
- Plant origin
- Vegan and vegetarian
- GMP + FDA registered facility
Category Whitespace
Most recovery products still rely on single-active curcumin or green coffee stories. A co-processed dual polyphenol with its own clinical file is rare shelf real estate.
- Differentiated vs single-active SKUs
- Proprietary branded positioning
- Story ready for marketing
How Gremin® compares to common recovery approaches.
Many recovery products ride on a single actives story. See how a co-processed dual polyphenol compares with standalone curcumin, standalone green coffee, and BCAA-only recovery formats.
| Feature | Gremin® | Standalone Curcumin | Standalone Green Coffee | BCAA Recovery |
|---|---|---|---|---|
| Active Ingredients | Dual polyphenol (curcumin + chlorogenic acid) | Curcuminoids only | Chlorogenic acid only | Amino acids |
| Human Clinical Studies | Two RCTs, both published | Varies by brand | Varies by brand | Category-level evidence |
| Daily Clinical Dose | 500 mg | Often 1,000 mg+ | Often 400 mg+ | 5 to 15 g |
| Strength Claim Support | Isometric strength significantly improved | Limited | Limited | Indirect |
| Endurance Claim Support | 6-minute walk test significantly improved | Limited | Mechanistic only | Indirect |
| Recovery / Soreness Support | VAS pain, LDH, and CRP improvements | Typically soreness only | Limited | Typically soreness only |
| Positioning | Natural, plant-based, branded | Natural, commodity | Natural, commodity | Often synthetic pathway |
Built for the formats today's consumers actually buy.
Gremin® is a water dispersible powder with a neutral profile, which means it plays well across the sports nutrition aisle. Keep your hero SKU on shelf and add Gremin® as the recovery and endurance layer.
Five stories you can tell on pack.
Each one is anchored in Gremin® clinical or mechanistic evidence.
Ready to build your next recovery SKU?
Whether you are launching a protein line with a built-in recovery story, a capsule for active adults, or a single-serve RTD for the training crowd, Gremin® gives you one clinically validated actives system to anchor the claim set.
- Clinical dose of 500 mg once daily
- Dual polyphenol, water dispersible powder
- Vegan, clean label, natural positioning
- Synergistic with protein, pre-workout, and standalone formats
Request samples, full specs, the published clinical study, and pricing. Our applications team will help scope your target dose, format, and timing.
Talk to Sales Download Product BrochureSamples, specs, and pricing available upon request
Frequently Asked Questions
Common questions from R&D, regulatory, and brand teams.
What is Gremin® made from?
Gremin® is a proprietary ingredient that co-processes green coffee bean extract (Coffea arabica, standardized to chlorogenic acid) with turmeric extract (Curcuma longa, standardized to curcuminoids) into a single food ingredient carrier. It is the first commercially available dual polyphenol system for sports and active nutrition.
What is the clinically studied dose?
The published clinical work used 500 mg once daily for 14 days. That dose produced significant improvements in 6-minute walk test distance and speed, isometric muscle strength of the non-dominant hand, total MFI fatigue score, and LDH muscle damage marker versus placebo.
How does Gremin® fit with protein powders?
Gremin® was designed to blend with protein supplements. It is water dispersible, has a neutral profile at normal inclusion, and is typically added to whey, plant, and beef protein systems to add a recovery, endurance, and lean-mass story without changing the protein content or sensory profile of the hero SKU.
Is Gremin® vegan and clean label?
Yes. Gremin® is 100% plant-derived from green coffee beans and turmeric, which makes it suitable for vegan and vegetarian formulas. It is manufactured in a GMP-certified, FDA-registered facility aligned with ISO 9001:2015 standards.
What categories is Gremin® best suited for?
Gremin® performs well across:
- Protein powders (whey, plant, and beef)
- Pre-workout and post-workout formulas
- Recovery capsules and tablets
- RTD recovery beverages
- Stick packs and sachets
- Gummies, chews, and ODF strips
Target users include serious athletes, weekend warriors, and active adults who train multiple times per week.
What claims can I build on Gremin®?
Structure-function claim directions supported by the published clinical evidence include supports muscle recovery, helps maintain endurance, supports muscle strength, helps reduce exercise-related fatigue, and supports post-workout repair. Specific claim language should be reviewed with your regulatory counsel for your target market.
Is Gremin® safe?
In the 60-subject healthy adult study, no clinically significant changes were observed in vital signs, complete blood count, liver enzymes (AST/ALT), or serum creatinine. No treatment-related adverse events were reported. An earlier acute oral toxicity study under OECD guideline 423 showed an LD50 greater than 5000 mg/kg in female Wistar rats. As with any ingredient, final product safety should be evaluated in the finished formula.
How do I request samples and specs?
Reach out through our Talk to Sales button or email sales@selectingredients.com. Typical response time is one business day. We will share samples, specification sheets, the published clinical study, and pricing based on your target format and volume.