--- title: SIVI Passion Flower Extract description: Elevate your formulations with SIVI, a high-GABA Passionflower extract proven to improve sleep, reduce stress, and enhance mood. 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A single **600 mg daily dose at bedtime** for 30 days delivered significant improvements in sleep onset, total sleep time, perceived stress, and daytime function in a **randomized, double-blind, placebo-controlled study**. ≥5% Vitexin Standardized 600 mg Clinical Dose Naturally High in GABA Hormone & Melatonin Free Published RCT [Talk to Sales](https://selectingredients.com/contact-us) [Download Product Brochure](https://selectingredients.com/hubfs/SIVI%20Passion%20Flower%20Infographic%20(8).pdf) Typical response: **1 business day** • Samples, specs, and pricing available upon request ![SIVI Passion Flower Extract Logo](https://selectingredients.com/hubfs/Product%20Logos/SIVI%20-%20White%20Square%20(8).png) SIVI™ Snapshot Sleep & stress Faster Sleep Onset −41% Clinical Dose 600 mg / day 30-day study Once daily At bedtime Format Stable, Soluble Powder Light brown, free-flowing dry extract that fits a full clinical dose in a single "00" capsule, gummy, stick pack, or RTD. Sourced from a proprietary high-vitexin cultivar of Passiflora incarnata, re-propagated from select mother roots for consistency. The Ingredient ## What is SIVI™? SIVI™ is a clinically studied **Passiflora incarnata (passion flower) extract** developed for sleep and stress applications. It is standardized to **≥5% vitexin** and naturally rich in **GABA**, the two compound classes responsible for passion flower's calming activity. Backed by a 65-subject randomized, double-blind, placebo-controlled clinical study published in *Cureus* (2024), SIVI™ delivers measurable sleep and stress benefits at a 600 mg once-daily dose. ### Proprietary High-Vitexin Cultivar SIVI™ starts with a proprietary variety of Passiflora incarnata selected for its exceptionally high vitexin and GABA content. The plant is **re-propagated from select mother roots** rather than from seed, locking in genetic potency and ensuring batch-to-batch consistency. ### Clinically Validated in Adults A 30-day, 65-subject randomized, double-blind, placebo-controlled study in adults with stress and insomnia showed **statistically significant improvements** in sleep onset, total sleep time, perceived stress, insomnia severity, and daytime fatigue versus placebo. ### Hormone-Free, Clean Label SIVI™ is 100% Passiflora incarnata aerial-herb extract with **no melatonin, no hormones, and no synthetic actives**. Non-GMO, non-irradiated, allergen-free, and tested by ICP-MS for heavy metals on every lot. Built for hormone-free sleep and stress positioning. ### Built for Modern Sleep & Calm Formats A stable, soluble dry powder that fits the full clinical dose in a single "00" capsule and works in gummies, stick packs, and RTD beverages. One ingredient that anchors both sleep **and** daytime stress positioning, simpler labels and lower cost-in-use. [Talk to Sales](https://selectingredients.com/contact-us) [Download Product Brochure](https://selectingredients.com/hubfs/SIVI%20Passion%20Flower%20Infographic%20(8).pdf) The Dual-Pathway Advantage ## Two calming pathways. One clean-label plant. SIVI™ works on the same biology your customers' bodies already use to wind down. Rather than forcing sedation, it supports two complementary pathways: GABA-ergic modulation that quiets neural overactivity, and a high-vitexin flavonoid system that buffers the stress response. Naturally Occurring GABA Sleep Onset & Depth GABA is the central nervous system's primary inhibitory neurotransmitter. Passion flower has been shown to contain among the **highest natural GABA content of any examined plant**. SIVI™ supports GABA-ergic activity to quiet hyperactive neurons so sleep can begin and deepen. - Shortens time to fall asleep - Supports deeper, more restorative sleep - Reduces middle-of-the-night awakenings - Quiets racing pre-sleep thoughts High-Vitexin Flavonoids Stress & Daytime Calm Standardized to ≥5% vitexin and naturally rich in **isovitexin, orientin, and homo-orientin**. These apigenin-derived flavonoids work synergistically to temper the stress response and provide antioxidant neuroprotection, supporting a calm mood and clear daytime focus. - Lowers perceived stress (PSS) - Buffers morning cortisol response - Supports daytime mood and focus - Antioxidant neuroprotection #### One Ingredient, 24-Hour Coverage When standardized together in SIVI™, GABA and vitexin-rich flavonoids cover both halves of the day deeper, more efficient sleep at night, and a calmer, sharper baseline mood the next morning. That 24-hour story lets a single ingredient anchor both nighttime sleep products and daytime stress formulas on the same shelf. Clinical Evidence ## 30 nights. Placebo controlled. Statistically significant. Published in *Cureus* (2024), the study enrolled 65 adults with stress and insomnia and randomized them to **600 mg SIVI™ or placebo once daily at bedtime for 30 days**. Sleep, stress, and daytime function were assessed using validated instruments including the Perceived Stress Scale, Insomnia Severity Index, Pittsburgh Sleep Quality Index, and Fatigue Severity Scale. SIVI™ vs. Placebo % Change from Baseline / Day 30 n = 65, RCT Time to Fall Asleep −41% vs −12% −41% −12% Number of Awakenings −67% vs −19% −67% −19% Insomnia Severity (ISI) −35% vs −8% −35% −8% Perceived Stress (PSS) −28% vs −8% −28% −8% Daytime Fatigue (FSS) −40% vs −10% −40% −10% SIVI™ 600 mg Placebo ### Study Highlights - Faster Sleep Onset Time to fall asleep dropped from **72 minutes at baseline to 43 minutes at Day 30** in the SIVI™ group, a 41% reduction (P\<0.05 vs. placebo). - More Total Sleep Average total sleep time increased **from 5.25 to 5.95 hours per night**, roughly 40 extra minutes of sleep, with no significant change in the placebo group. - Better Sleep Efficiency Sleep efficiency improved **from 75.5% to 86.6%** in the SIVI™ group, versus a negligible change in placebo. - Lower Stress & Cortisol Perceived Stress Scale dropped from 21 to 15. Morning serum cortisol declined **17% versus 11% in placebo**, while remaining within normal range in both groups. - Sharper Daytime Function **Significantly less interference of sleep on daytime mood, ability to function at work, concentration, and memory** in the SIVI™ group vs. placebo at Day 15 and Day 30. - Clean Safety Profile **Zero adverse events.** Complete blood count, liver and renal function, lipid profile, and fasting blood sugar remained within normal range. No rescue sedatives required. Harit M, et al. Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora incarnata in Participants With Stress and Sleep Problems. **Cureus**, March 2024. DOI 10.7759/cureus.56530. CTRI/2022/07/043753. Conducted per ICH-GCP. Why Formulators Choose SIVI™ ## A different category from commodity passion flower. Most passion flower on the market is uncharacterized leaf powder with no human clinical data behind the specific material. SIVI™ is a defined, clinically studied extract that gives brands a real claim set in one ingredient. ### Standardized to ≥5% Vitexin Verified by **HPLC on every lot**. Naturally rich in vitexin, isovitexin, orientin, homo-orientin, and GABA, the compound classes responsible for passion flower's clinical activity. - ≥5% total flavonoids as vitexin - 8:1 extract ratio - HPLC verified each batch ### Published Human RCT Peer-reviewed and published in *Cureus*. A 65-subject randomized, double-blind, placebo-controlled study using validated sleep and stress instruments on the exact extract sold. - Randomized, double-blind, placebo-controlled - Validated PSS, ISI, PSQI, FSS instruments - CTRI registered and ICH-GCP compliant ### One-Capsule Clinical Dose The full **600 mg clinical dose fits in a single "00" capsule**. Cleaner label, lower cost-in-use, and easy to anchor a single-serve claim across capsules, gummies, stick packs, and RTDs. - 600 mg in one capsule - 300 mg × 2 in gummies - Soluble for stick packs and beverages ### Hormone-Free & Clean Label No melatonin, no hormones, no synthetic actives. **Non-GMO, non-irradiated, allergen-free**, and tested by ICP-MS for heavy metals on every lot. Perfect fit for hormone-free sleep positioning. - Melatonin-free sleep claim - Heavy metals tested by ICP-MS - Non-GMO, allergen-free ### Sleep + Stress in One Ingredient Replaces multi-ingredient stacks (valerian + melatonin + L-theanine + magnesium) with one science-backed botanical. **Simpler labels**, fewer SKUs, and a single sustainability story to tell at retail. - Both sleep and stress endpoints - 24-hour positioning - Replaces 3-4 stacked actives ### Category Tailwind Sleep and stress are among the fastest-growing supplement categories, and consumers are actively rotating away from hormonal sleep aids. **A clinically backed, hormone-free option** is rare shelf real estate. - $11.8B sleep aid market by 2034 - Hormone-free shopper rotation - Differentiated vs melatonin SKUs SIVI™ vs. The Rest ## How SIVI™ compares to common sleep & stress ingredients. Most sleep ingredients win on one axis and lose on another, either they sedate hard with morning fog, or they're gentle but unproven. See how SIVI™ stacks up against the most common alternatives formulators evaluate. | Feature | SIVI™ Passion Flower | Generic Passion Flower | Melatonin | Valerian Root | | --- | --- | --- | --- | --- | | Active Standardization | ≥5% vitexin + natural GABA | Variable / none | N/A (synthetic hormone) | Valerenic acid (variable) | | Published RCT on this extract | Yes, n=65, 30 days (Cureus 2024) | No | Varies by brand | Mixed evidence | | Daily Clinical Dose | 600 mg | 500 to 1000 mg (unproven) | 0.5 to 5 mg | 300 to 600 mg | | Sleep Onset Support | −41% time to sleep | Limited | Moderate | Moderate | | Stress Support | Yes, validated (PSS) | Anecdotal | No | Limited | | Morning Grogginess Risk | Low | Low | Moderate to high | Moderate | | Taste in Beverages | Mild, neutral | Grassy | Neutral | Strong, off-putting | | Hormone-Free | Yes | Yes | No (is a hormone) | Yes | Comparison based on typical commercial offerings. Specific performance depends on the finished product, dose, and source material. Formulating With SIVI™ ## Built for the sleep & calm formats consumers reach for. SIVI™ is a stable, soluble dry powder with a 600 mg clinical dose. That makes it straightforward to hit a single-serve sleep or stress claim in the formats consumers are already buying. Bedtime Capsules Full 600 mg dose in a single "00" Sleep & Calm Gummies 300 mg × 2 daily dose Stick Packs Hot or cold, on-the-go calm Relaxation RTDs Shots and functional beverages Softgels Premium sleep softgel SKUs Sleep Teas Bedtime herbal blends Functional Powders Calm and recovery stacks Tablets & Chews Pressed sleep aids and chewables Clinical Use Dose 600 mg / day Taken once daily at bedtime. Clinical outcomes measured at Day 15 and Day 30. The full dose fits in a single "00" capsule, splits cleanly across two 300 mg gummies, and dissolves in hot or cold liquids without grit. Consumer Benefits ## Five stories you can tell on pack. Each one anchored in the SIVI™ randomized, placebo-controlled clinical study. Falls Asleep Faster −41% time to sleep onset More Total Sleep ~40 extra minutes per night Calmer Stress Response Lower PSS and cortisol Fewer Awakenings −67% nightly awakenings Sharper Next Day Better mood, focus, energy ## Ready to launch your next sleep or calm SKU? Whether you are building a melatonin-free bedtime capsule, a stress-relief gummy, a relaxation beverage, or a 24-hour calm stack, SIVI™ gives you one clinically validated ingredient to anchor the whole claim set. - 600 mg clinical dose, 30-day visible window - Standardized to ≥5% vitexin with natural GABA - Hormone-free, non-GMO, allergen-free - Local San Diego inventory for fast turnaround Talk to our team Request samples, full specs, the published clinical study, and pricing. Our applications team will help scope your target dose, format, and claim language. [Talk to Sales](https://selectingredients.com/contact-us) [Download Product Brochure](https://selectingredients.com/hubfs/SIVI%20Passion%20Flower%20Infographic%20(8).pdf) Typical response: **1 business day** Samples, specs, and pricing available upon request FAQ ## Frequently Asked Questions Common questions from R&D, regulatory, and brand teams. What is SIVI™ made from? SIVI™ is a dry extract of **Passiflora incarnata (passion flower) aerial herb**, sourced from a proprietary high-vitexin, high-GABA cultivar. It is an **8:1 extract standardized to ≥5% total flavonoids as vitexin** by HPLC, with naturally occurring GABA and related flavonoids including isovitexin, orientin, and homo-orientin. What is the clinically studied dose? The published clinical work used **600 mg once daily at bedtime for 30 days**. That dose produced statistically significant improvements in time to fall asleep, total sleep time, number of awakenings, sleep efficiency, insomnia severity (ISI), perceived stress (PSS), daytime fatigue (FSS), and overall sleep quality (PSQI) versus placebo. What formats does SIVI™ work in? SIVI™ is a stable, free-flowing powder built for: - Bedtime capsules (full 600 mg dose in a single "00") - Sleep and calm gummies (300 mg × 2) - Hot and cold stick packs - Relaxation shots and RTD beverages - Softgels, tablets, and chews - Sleep tea blends - Functional calm and recovery powders How is SIVI™ different from generic passion flower? Most commercial passion flower is uncharacterized leaf powder with no standardization and no human clinical data behind the specific material. SIVI™ uses a **proprietary high-vitexin cultivar**, is standardized to ≥5% vitexin, and is supported by a **published randomized controlled trial on the exact extract being sold**. Does SIVI™ contain melatonin or other hormones? No. SIVI™ is 100% Passiflora incarnata aerial-herb extract with **no added hormones, no melatonin, and no synthetic actives**. That makes it a strong fit for hormone-free, clean-label sleep and stress formulas. What claims can I build on SIVI™? Structure-function claim directions supported by the published clinical evidence include **helps support sleep onset, helps maintain healthy sleep duration, supports a calm mood and healthy stress response, supports next-day mood and focus**, and **provides a non-hormonal sleep ingredient**. Specific claim language should be reviewed with your regulatory counsel for your target market. Is SIVI™ safe? In the 65-subject clinical study, **no adverse events were reported**. Complete blood count, liver function tests, renal function tests, lipid profile, and fasting blood sugar all remained within normal range. No participants required rescue sedatives. Every lot of SIVI™ is tested for heavy metals (ICP-MS), microbials, and pathogens. How do I request samples and specs? Reach out through the **Talk to Sales** button or email sales@selectingredients.com. Typical response time is one business day. SIVI™ is stocked in our **San Diego warehouse**, so samples and bulk orders typically ship faster than direct import. [linkedin-in icon](https://www.linkedin.com/company/select-ingredients/) - [All Ingredients](https://selectingredients.com/all-ingredients) - [About Us](https://selectingredients.com/about-us) - [Blog](https://selectingredients.com/blog) - [Contact Us](https://selectingredients.com/contact-us) --- [![Select Ingredients Logo](https://selectingredients.com/hs-fs/hubfs/SI_Final-2%20(1).jpg?width=618&height=184&name=SI_Final-2%20(1).jpg "Select Ingredients Logo")](https://selectingredients.com) 10366 Roselle Street, Suite A, San Diego CA 92101  Copyright © 2026, Select Ingredients