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Clinically Studied Passion Flower for Sleep & Stress
SIVI™ is a clinically validated Passiflora incarnata extract standardized to 5% vitexin and naturally rich in GABA. A single 600 mg daily dose at bedtime for 30 days delivered significant improvements in sleep onset, total sleep time, perceived stress, and daytime function in a randomized, double-blind, placebo-controlled study.
What is SIVI™?
SIVI™ is a clinically studied Passiflora incarnata (passion flower) extract developed for sleep and stress applications. It is standardized to ≥5% vitexin and naturally rich in GABA, the two compound classes responsible for passion flower's calming activity. Backed by a 65-subject randomized, double-blind, placebo-controlled clinical study published in Cureus (2024), SIVI™ delivers measurable sleep and stress benefits at a 600 mg once-daily dose.
Proprietary High-Vitexin Cultivar
SIVI™ starts with a proprietary variety of Passiflora incarnata selected for its exceptionally high vitexin and GABA content. The plant is re-propagated from select mother roots rather than from seed, locking in genetic potency and ensuring batch-to-batch consistency.
Clinically Validated in Adults
A 30-day, 65-subject randomized, double-blind, placebo-controlled study in adults with stress and insomnia showed statistically significant improvements in sleep onset, total sleep time, perceived stress, insomnia severity, and daytime fatigue versus placebo.
Hormone-Free, Clean Label
SIVI™ is 100% Passiflora incarnata aerial-herb extract with no melatonin, no hormones, and no synthetic actives. Non-GMO, non-irradiated, allergen-free, and tested by ICP-MS for heavy metals on every lot. Built for hormone-free sleep and stress positioning.
Built for Modern Sleep & Calm Formats
A stable, soluble dry powder that fits the full clinical dose in a single "00" capsule and works in gummies, stick packs, and RTD beverages. One ingredient that anchors both sleep and daytime stress positioning, simpler labels and lower cost-in-use.
Two calming pathways. One clean-label plant.
SIVI™ works on the same biology your customers' bodies already use to wind down. Rather than forcing sedation, it supports two complementary pathways: GABA-ergic modulation that quiets neural overactivity, and a high-vitexin flavonoid system that buffers the stress response.
GABA is the central nervous system's primary inhibitory neurotransmitter. Passion flower has been shown to contain among the highest natural GABA content of any examined plant. SIVI™ supports GABA-ergic activity to quiet hyperactive neurons so sleep can begin and deepen.
- Shortens time to fall asleep
- Supports deeper, more restorative sleep
- Reduces middle-of-the-night awakenings
- Quiets racing pre-sleep thoughts
Standardized to ≥5% vitexin and naturally rich in isovitexin, orientin, and homo-orientin. These apigenin-derived flavonoids work synergistically to temper the stress response and provide antioxidant neuroprotection, supporting a calm mood and clear daytime focus.
- Lowers perceived stress (PSS)
- Buffers morning cortisol response
- Supports daytime mood and focus
- Antioxidant neuroprotection
One Ingredient, 24-Hour Coverage
When standardized together in SIVI™, GABA and vitexin-rich flavonoids cover both halves of the day deeper, more efficient sleep at night, and a calmer, sharper baseline mood the next morning. That 24-hour story lets a single ingredient anchor both nighttime sleep products and daytime stress formulas on the same shelf.
30 nights. Placebo controlled. Statistically significant.
Published in Cureus (2024), the study enrolled 65 adults with stress and insomnia and randomized them to 600 mg SIVI™ or placebo once daily at bedtime for 30 days. Sleep, stress, and daytime function were assessed using validated instruments including the Perceived Stress Scale, Insomnia Severity Index, Pittsburgh Sleep Quality Index, and Fatigue Severity Scale.
Study Highlights
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Faster Sleep Onset
Time to fall asleep dropped from 72 minutes at baseline to 43 minutes at Day 30 in the SIVI™ group, a 41% reduction (P<0.05 vs. placebo).
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More Total Sleep
Average total sleep time increased from 5.25 to 5.95 hours per night, roughly 40 extra minutes of sleep, with no significant change in the placebo group.
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Better Sleep Efficiency
Sleep efficiency improved from 75.5% to 86.6% in the SIVI™ group, versus a negligible change in placebo.
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Lower Stress & Cortisol
Perceived Stress Scale dropped from 21 to 15. Morning serum cortisol declined 17% versus 11% in placebo, while remaining within normal range in both groups.
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Sharper Daytime Function
Significantly less interference of sleep on daytime mood, ability to function at work, concentration, and memory in the SIVI™ group vs. placebo at Day 15 and Day 30.
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Clean Safety Profile
Zero adverse events. Complete blood count, liver and renal function, lipid profile, and fasting blood sugar remained within normal range. No rescue sedatives required.
A different category from commodity passion flower.
Most passion flower on the market is uncharacterized leaf powder with no human clinical data behind the specific material. SIVI™ is a defined, clinically studied extract that gives brands a real claim set in one ingredient.
Standardized to ≥5% Vitexin
Verified by HPLC on every lot. Naturally rich in vitexin, isovitexin, orientin, homo-orientin, and GABA, the compound classes responsible for passion flower's clinical activity.
- ≥5% total flavonoids as vitexin
- 8:1 extract ratio
- HPLC verified each batch
Published Human RCT
Peer-reviewed and published in Cureus. A 65-subject randomized, double-blind, placebo-controlled study using validated sleep and stress instruments on the exact extract sold.
- Randomized, double-blind, placebo-controlled
- Validated PSS, ISI, PSQI, FSS instruments
- CTRI registered and ICH-GCP compliant
One-Capsule Clinical Dose
The full 600 mg clinical dose fits in a single "00" capsule. Cleaner label, lower cost-in-use, and easy to anchor a single-serve claim across capsules, gummies, stick packs, and RTDs.
- 600 mg in one capsule
- 300 mg × 2 in gummies
- Soluble for stick packs and beverages
Hormone-Free & Clean Label
No melatonin, no hormones, no synthetic actives. Non-GMO, non-irradiated, allergen-free, and tested by ICP-MS for heavy metals on every lot. Perfect fit for hormone-free sleep positioning.
- Melatonin-free sleep claim
- Heavy metals tested by ICP-MS
- Non-GMO, allergen-free
Sleep + Stress in One Ingredient
Replaces multi-ingredient stacks (valerian + melatonin + L-theanine + magnesium) with one science-backed botanical. Simpler labels, fewer SKUs, and a single sustainability story to tell at retail.
- Both sleep and stress endpoints
- 24-hour positioning
- Replaces 3-4 stacked actives
Category Tailwind
Sleep and stress are among the fastest-growing supplement categories, and consumers are actively rotating away from hormonal sleep aids. A clinically backed, hormone-free option is rare shelf real estate.
- $11.8B sleep aid market by 2034
- Hormone-free shopper rotation
- Differentiated vs melatonin SKUs
How SIVI™ compares to common sleep & stress ingredients.
Most sleep ingredients win on one axis and lose on another, either they sedate hard with morning fog, or they're gentle but unproven. See how SIVI™ stacks up against the most common alternatives formulators evaluate.
| Feature | SIVI™ Passion Flower | Generic Passion Flower | Melatonin | Valerian Root |
|---|---|---|---|---|
| Active Standardization | ≥5% vitexin + natural GABA | Variable / none | N/A (synthetic hormone) | Valerenic acid (variable) |
| Published RCT on this extract | Yes, n=65, 30 days (Cureus 2024) | No | Varies by brand | Mixed evidence |
| Daily Clinical Dose | 600 mg | 500 to 1000 mg (unproven) | 0.5 to 5 mg | 300 to 600 mg |
| Sleep Onset Support | −41% time to sleep | Limited | Moderate | Moderate |
| Stress Support | Yes, validated (PSS) | Anecdotal | No | Limited |
| Morning Grogginess Risk | Low | Low | Moderate to high | Moderate |
| Taste in Beverages | Mild, neutral | Grassy | Neutral | Strong, off-putting |
| Hormone-Free | Yes | Yes | No (is a hormone) | Yes |
Built for the sleep & calm formats consumers reach for.
SIVI™ is a stable, soluble dry powder with a 600 mg clinical dose. That makes it straightforward to hit a single-serve sleep or stress claim in the formats consumers are already buying.
Five stories you can tell on pack.
Each one anchored in the SIVI™ randomized, placebo-controlled clinical study.
Ready to launch your next sleep or calm SKU?
Whether you are building a melatonin-free bedtime capsule, a stress-relief gummy, a relaxation beverage, or a 24-hour calm stack, SIVI™ gives you one clinically validated ingredient to anchor the whole claim set.
- 600 mg clinical dose, 30-day visible window
- Standardized to ≥5% vitexin with natural GABA
- Hormone-free, non-GMO, allergen-free
- Local San Diego inventory for fast turnaround
Request samples, full specs, the published clinical study, and pricing. Our applications team will help scope your target dose, format, and claim language.
Talk to Sales Download Product BrochureSamples, specs, and pricing available upon request
Frequently Asked Questions
Common questions from R&D, regulatory, and brand teams.
What is SIVI™ made from?
SIVI™ is a dry extract of Passiflora incarnata (passion flower) aerial herb, sourced from a proprietary high-vitexin, high-GABA cultivar. It is an 8:1 extract standardized to ≥5% total flavonoids as vitexin by HPLC, with naturally occurring GABA and related flavonoids including isovitexin, orientin, and homo-orientin.
What is the clinically studied dose?
The published clinical work used 600 mg once daily at bedtime for 30 days. That dose produced statistically significant improvements in time to fall asleep, total sleep time, number of awakenings, sleep efficiency, insomnia severity (ISI), perceived stress (PSS), daytime fatigue (FSS), and overall sleep quality (PSQI) versus placebo.
What formats does SIVI™ work in?
SIVI™ is a stable, free-flowing powder built for:
- Bedtime capsules (full 600 mg dose in a single "00")
- Sleep and calm gummies (300 mg × 2)
- Hot and cold stick packs
- Relaxation shots and RTD beverages
- Softgels, tablets, and chews
- Sleep tea blends
- Functional calm and recovery powders
How is SIVI™ different from generic passion flower?
Most commercial passion flower is uncharacterized leaf powder with no standardization and no human clinical data behind the specific material. SIVI™ uses a proprietary high-vitexin cultivar, is standardized to ≥5% vitexin, and is supported by a published randomized controlled trial on the exact extract being sold.
Does SIVI™ contain melatonin or other hormones?
No. SIVI™ is 100% Passiflora incarnata aerial-herb extract with no added hormones, no melatonin, and no synthetic actives. That makes it a strong fit for hormone-free, clean-label sleep and stress formulas.
What claims can I build on SIVI™?
Structure-function claim directions supported by the published clinical evidence include helps support sleep onset, helps maintain healthy sleep duration, supports a calm mood and healthy stress response, supports next-day mood and focus, and provides a non-hormonal sleep ingredient. Specific claim language should be reviewed with your regulatory counsel for your target market.
Is SIVI™ safe?
In the 65-subject clinical study, no adverse events were reported. Complete blood count, liver function tests, renal function tests, lipid profile, and fasting blood sugar all remained within normal range. No participants required rescue sedatives. Every lot of SIVI™ is tested for heavy metals (ICP-MS), microbials, and pathogens.
How do I request samples and specs?
Reach out through the Talk to Sales button or email sales@selectingredients.com. Typical response time is one business day. SIVI™ is stocked in our San Diego warehouse, so samples and bulk orders typically ship faster than direct import.