--- title: Grantria® | Clinically Studied Pomegranate Extract for Skin Health description: Grantria® is a triple-active pomegranate extract standardized to ellagic acid, punicic acid, and punicalagin. 48% reduction in crow's feet and 42.8% skin radiance improvement at 300 mg/day. Request samples and pricing. --- [Skip to content](https://selectingredients.com/grantria#main-content) ![Select Ingredients Logo](https://selectingredients.com/hs-fs/hubfs/SI_Final-2%20(1).jpg?width=618&height=184&name=SI_Final-2%20(1).jpg) Open main navigation Close main navigation - [Contact us](https://selectingredients.com/grantria#contact) [Contact us](https://selectingredients.com/grantria#contact) Grantria® | Clinically Studied Pomegranate Extract for Skin Health | Wholesale Nutricosmetic Supplier Wholesale Ingredient # Triple-Active Pomegranate Extract for Beauty from Within Grantria® is a **clinically validated pomegranate extract** standardized to three bioactives ellagic acid, punicic acid, and punicalagin, plus trace plant vitamin C and zinc. A single **300 mg daily dose for 60 days** delivered a 48% reduction in crow's feet and a 42.8% gain in skin radiance versus placebo in a **randomized, placebo-controlled study**. Triple-Active Standardized 300 mg Clinical Dose Clean Label Project Certified Vegan & Plant-Based Health Canada NPN [Talk to Sales](https://selectingredients.com/contact-us) Download Product Brochure Typical response: **1 business day** • Samples, specs, and pricing available upon request Gran*tria*® Grantria® Snapshot Beauty-from-within Crow's Feet Reduction 48% Clinical Dose 300 mg / day 60-day study Once daily Before food Format Stable, Soluble Powder Built with ADOP (Advanced Oil-to-Powder) technology for consistency across gummies, stick packs, softgels, and tablets. World's first triple-active pomegranate extract standardized to ellagic acid, punicic acid, and punicalagin for nutricosmetic use. The Ingredient ## What is Grantria®? Grantria® is a proprietary pomegranate extract (Punica granatum) developed using **ADOP (Advanced Oil-to-Powder) technology**. It is the first pomegranate ingredient standardized to **all three signature bioactives** ellagic acid, punicic acid, and punicalagin plus trace amounts of plant-derived vitamin C and zinc for synergistic collagen and antioxidant support. A 60-day randomized, placebo-controlled clinical study in 60 women validated its skin health benefits at a 300 mg daily dose. ### Built on ADOP Technology Advanced Oil-to-Powder processing converts lipophilic pomegranate seed bioactives into a **stable, soluble, clean-label powder**. The result is better formulation flexibility across gummies, stick packs, softgels, capsules, and tablets without solvent residue concerns. ### Clinically Validated in Women A 60-day, 60-subject randomized, placebo-controlled trial in women aged 35 to 65 showed **significant improvements** in crow's feet wrinkles, tactile roughness, forehead fine lines, forehead wrinkles, and skin radiance versus placebo. ### Clean Label and Globally Compliant Grantria® is **Clean Label Project certified** and holds a **Health Canada NPN (80135552)**. Produced in a GMP-certified, FDA-registered facility aligned with ISO 9001:2015. A plant-derived, vegan, nutricosmetic ready actives system. ### Built for the Women's Wellness Shelf Beyond visible skin benefits, pomegranate bioactives are studied for **antioxidant, hormonal balance, and healthy aging support**. That lets brands position Grantria® as a single ingredient anchor for skin, menopause, and overall women's wellness SKUs. [Talk to Sales](https://selectingredients.com/contact-us) Download Product Brochure The Triple-Active Advantage ## Three pomegranate bioactives. One synergistic system. Most pomegranate extracts isolate one or two polyphenols. Grantria® delivers all three signature bioactives in calibrated ratios so each pathway in the skin aging story is covered from antioxidant defense to collagen support to pigmentation control. Ellagic Acid Tone & Pigmentation A polyphenol studied in oral and topical work for UV-induced pigmentation control. Inhibits tyrosinase activity, a key enzyme in melanin formation. - Supports even skin tone - Tyrosinase activity modulation - UV pigmentation defense - Antioxidant activity Punicic Acid Barrier & Moisture A rare omega-5 conjugated fatty acid from pomegranate seed oil. Reported to support the integrity of the epidermis and healthy skin barrier function. - Epidermal barrier support - Skin moisturization - Lipid membrane integrity - Conjugated fatty acid activity Punicalagin Antioxidant & Repair A large polyphenol documented to protect DNA from oxidative damage, reduce keratinocyte stress, and support wound healing and cell adhesion in published research. - Oxidative stress protection - DNA damage defense - Keratinocyte support - Wound healing activity #### The Triple-Active Outcome When standardized together in Grantria®, these three bioactives target the pillars of skin aging in parallel: visible wrinkles and fine lines, tactile roughness, pigmentation and skin tone, and barrier and moisture. Trace plant vitamin C and zinc round out the collagen and antioxidant story for a complete beauty-from-within ingredient. Clinical Evidence ## 60 days. Dermatologist-scored. Placebo controlled. Published in the American Journal of Translational Research, the study enrolled 60 women aged 35 to 65 and randomized them to **300 mg Grantria® or placebo once daily for 60 days**. Skin was scored by a dermatologist using the Bazin and Flament skin aging atlas, and measured with Visioscan® topography and Cutometer® elasticity instrumentation. Grantria® vs. Placebo % Change / Day 60 n = 60, RCT Crow's Feet Wrinkles -48% vs +10% -48% +10% Skin Radiance +42.8% vs -3.9% +42.8% -3.9% Tactile Roughness -43.3% vs +6.9% -43.3% +6.9% Forehead Fine Lines -45% vs +10.9% -45% +10.9% Forehead Wrinkles -39.7% vs +7.4% -39.7% +7.4% Grantria® 300 mg Placebo ### Study Highlights - Dermatologist Scoring **Significant reductions** (P<0.001) in crow's feet, tactile roughness, forehead fine lines, and forehead wrinkles versus placebo, scored on the Bazin and Flament skin aging atlas. - Visioscan® Topography **4.58% reduction in facial pores** (P<0.001) and **2.78% reduction in dark spots** (P<0.005) from baseline at Day 60. - Skin Tone & UV Pigmentation Significantly improved skin tone evenness and reduced UV pigmentation from baseline; placebo group showed opposite trends. - Elasticity & Moisturization **Cutometer®-measured elasticity and firmness improved** from baseline. Corneometer-measured skin moisturization improved significantly in the Grantria® group. - Subject Self-Report & Safety **97.5% of Grantria® users reported improved skin radiance** versus 35% in placebo. No adverse events reported during the study. Published in the American Journal of Translational Research, December 2024. Study registered in the Clinical Trials Registry of India (CTRI/2023/02/050063). Conducted per ICH-GCP and the Declaration of Helsinki. Why Formulators Choose Grantria® ## A complete beauty-from-within ingredient story. Nutricosmetics is one of the fastest moving categories in dietary supplements. Grantria® gives brands a clinically validated, triple-active pomegranate extract with global compliance credentials in one powder. ### Triple-Active Standardization Most pomegranate ingredients rely on one or two markers. Grantria® delivers all three signature bioactives, plus trace vitamin C and zinc for a fuller skin health story. - Ellagic acid for tone - Punicic acid for barrier - Punicalagin for antioxidant defense ### Published Human Clinical Study Peer-reviewed and published in the American Journal of Translational Research. A 60-subject randomized, placebo-controlled design with dermatologist-scored outcomes. - Dermatologist scoring - Visioscan® and Cutometer® instrumentation - Published and CTRI registered ### Visible Results at 300 mg Measurable gains at a **300 mg once-daily dose**, clinically studied over 60 days. Low-inclusion dosing makes gummies, stick packs, and softgels straightforward to formulate. - 300 mg clinical dose - Single capsule or gummy delivery - 60-day visible window ### Clean Label & Globally Compliant **Clean Label Project certified** and holds a **Health Canada NPN**. Produced in a GMP-certified, FDA-registered facility aligned with ISO 9001:2015 standards. - Clean Label Project certified - Health Canada NPN 80135552 - GMP + FDA registered facility ### Women's Wellness Crossover Skin is the entry point, but pomegranate bioactives are studied in hormonal, heart, and aging contexts. One ingredient that can anchor a whole women's wellness line. - Skin + hormonal health angle - Menopause positioning optional - Antioxidant support story ### Category Tailwind Beauty-from-within is one of the fastest growing nutricosmetic subcategories. A differentiated, clinically studied pomegranate extract is rare shelf real estate. - Nutricosmetic category growth - Differentiated vs collagen-only - Story ready for social and retail Grantria® vs. The Rest ## How Grantria® compares to common beauty-from-within ingredients. Most nutricosmetic products ride on a single-actives story. See how Grantria® compares with collagen peptides, resveratrol, and standard pomegranate extracts on claim support and evidence depth. | Feature | Grantria® | Collagen Peptides | Resveratrol | Standard Pomegranate | | --- | --- | --- | --- | --- | | Active Standardization | Ellagic acid + punicic acid + punicalagin | Hydrolyzed peptides | Trans-resveratrol | Usually ellagic acid only | | Human Clinical Study | Published RCT, n=60, 60 days | Varies by brand | Varies by brand | Varies by brand | | Daily Clinical Dose | 300 mg | 2.5 to 10 g | 150 to 500 mg | 250 mg to 1,000 mg | | Wrinkle Claim Support | Crow's feet, forehead lines and wrinkles | Varies | Limited | Limited | | Pigmentation Claim Support | Dark spots, UV pigmentation, skin tone | Limited | Mechanistic only | Limited | | Positioning | Natural, plant-based, branded | Animal-derived (usually) | Natural, commodity | Natural, commodity | | Label Credentials | Clean Label Project + Health Canada NPN | Varies | Varies | Varies | Comparison based on typical commercial offerings. Specific performance depends on the finished product, dose, and source material. Formulating With Grantria® ## Built for the formats today's beauty consumer reaches for. Grantria® is a stable, soluble powder with a 300 mg clinical dose. That makes it straightforward to hit a single-serve claim in the formats consumers already buy in the beauty-from-within aisle. Gummies Daily beauty gummies Stick Packs On-the-go beauty sachets Softgels Premium beauty softgels Capsules Classic daily beauty SKU Tablets Cost-effective beauty tablets Beauty RTDs Cold-dispersed beauty drinks ODF Strips Oral dissolving film delivery Collagen Stacks Synergistic collagen blends Clinical Use Dose 300 mg / day Taken once daily, before food. Clinical outcomes measured at Day 60. Low inclusion makes it easy to anchor a claim in a single gummy, softgel, stick pack, or capsule. Consumer Benefits ## Five stories you can tell on pack. Each one is anchored in Grantria® clinical evidence or published mechanistic research. Fewer Wrinkles Crow's feet and forehead lines Skin Radiance Brighter, more even glow Moisturization Hydrated, smoother feel Fewer Dark Spots Pigmentation and pore support Antioxidant Defense Protects from oxidative stress ## Ready to launch your next beauty-from-within SKU? Whether you are building a daily beauty gummy, a premium softgel, a collagen stack, or a full women's wellness line, Grantria® gives you one clinically validated, triple-active ingredient to anchor the claim set. - 300 mg clinical dose, 60-day visible window - Triple-active pomegranate standardization - Clean Label Project certified, Health Canada NPN - Stable, soluble, and formulation flexible across formats Talk to our team Request samples, full specs, the published clinical study, and pricing. Our applications team will help scope your target dose, format, and claim language. [Talk to Sales](https://selectingredients.com/contact-us) Download Product Brochure Typical response: **1 business day** Samples, specs, and pricing available upon request FAQ ## Frequently Asked Questions Common questions from R&D, regulatory, and brand teams. What is Grantria® made from? Grantria® is a proprietary **pomegranate (Punica granatum) extract** developed using ADOP (Advanced Oil-to-Powder) technology. It is standardized to three signature bioactives: **ellagic acid, punicic acid, and punicalagin**, with trace plant-derived vitamin C and zinc for synergistic collagen and antioxidant support. What is the clinically studied dose? The published clinical work used **300 mg once daily for 60 days**, taken before food. That dose produced significant improvements in crow's feet, forehead fine lines and wrinkles, tactile roughness, and skin radiance versus placebo, plus gains in pore count, dark spots, and skin tone evenness. What formats does Grantria® work in? Grantria® is a stable, soluble powder built to formulate cleanly across: - Gummies and chews - Stick packs and sachets - Softgels - Capsules and tablets - Beauty RTD beverages - Collagen and nutricosmetic stacks Target users are women aged 30 and up looking for an ingestible beauty-from-within ingredient. What is ADOP technology? ADOP stands for **Advanced Oil-to-Powder**. It is the proprietary clean-label process Zeus Hygia uses to convert lipophilic pomegranate seed bioactives into a stable, soluble, free-flowing powder without solvent residues. The result is better formulation flexibility and shelf stability compared to conventional oil extracts. Is Grantria® vegan and clean label? Yes. Grantria® is 100% plant-derived from pomegranate. It is **Clean Label Project certified** and holds a **Health Canada NPN (80135552)**. Produced in a GMP-certified, FDA-registered facility aligned with ISO 9001:2015 standards. What claims can I build on Grantria®? Structure-function claim directions supported by the published clinical evidence include **helps reduce the appearance of wrinkles and fine lines, supports skin radiance, helps maintain skin firmness and elasticity, supports even skin tone**, and **provides antioxidant support for healthy aging**. Specific claim language should be reviewed with your regulatory counsel for your target market. Is Grantria® safe? In the 60-subject clinical study, **no adverse events were reported**. Grantria® is produced under strict quality controls in a GMP-certified, FDA-registered facility, with every batch tested to Clean Label Project standards. As with any ingredient, finished product safety should be evaluated in the final formula. How do I request samples and specs? Reach out through the **Talk to Sales** button or email sales@selectingredients.com. Typical response time is one business day. 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